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Article

The DNA methylome of human sperm is distinct from blood with little evidence for tissue-consistent obesity associations.

PLoS genetics - 1 Oct 2020

Åsenius Fredrika, Gorrie-Stone Tyler J, Brew Ama, Panchbhaya Yasmin, Williamson Elizabeth, Schalkwyk Leonard C, Rakyan Vardhman K, Holland Michelle L, Marzi Sarah J, Williams David J

Abstract excerpt

Epidemiological research suggests that paternal obesity may increase the risk of fathering small for gestational age offspring. Studies in non-human mammals indicate that such associations could be mediated by DNA methylation changes in spermatozoa that influence offspring development in utero. Human obesity is associated with differential DNA methylation in peripheral blood. It is unclear, however, whether this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33048947
DOI: 10.1371/journal.pgen.1009035
PMCID: PMC7584170

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