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Paternal obesity induces epigenetic aberrations and gene expression changes in placenta and fetus

21 Dec 2022

Abstract excerpt

Paternal epigenome regulates placental and fetal growth. However, the effect of paternal obesity on placenta and its subsequent effect on the fetus via sperm remains unknown. We previously discovered abnormal methylation of imprinted genes involved in placental and fetal development in the spermatozoa of obese rats. In the present study, elaborate epigenetic characterization of sperm, placenta, and fetus was...

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Share to Epigenetics and DNA Methylation
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PMID: 36541371
DOI: 10.1002/mrd.23660

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