Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

How do lifestyle and environmental factors influence the sperm epigenome? Effects on sperm fertilising ability, embryo development, and offspring health

16 Jan 2025

Abstract excerpt

Recent studies support the influence of paternal lifestyle and diet before conception on the health of the offspring via epigenetic inheritance through sperm DNA methylation, histone modification, and small non-coding RNA (sncRNA) expression and regulation. Smoking may induce DNA hypermethylation in genes related to anti-oxidation and insulin resistance. Paternal diet and obesity are associated with greater risks...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Reproductive Biology and Fertility
Share to Reproductive Health and Technologies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39819375
DOI: 10.1186/s13148-025-01815-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

How do lifestyle and environmental factors influence the sperm epigenome? Effects on sperm fertilising ability, embryo development, and offspring healthPMID 39819375Read ↗

Sperm epigenetics and influence of environmental factorsSemantic proximity Read ↗

Epigenetic Mechanisms of Paternal Stress in Offspring Development and DiseasesSemantic proximity Read ↗

Effects of paternal overnutrition and interventions on future generationsSemantic proximity Read ↗

Epigenetic effects of paternal environmental exposures and experiences on offspring phenotypes.Semantic proximity Read ↗

Metabolic diseases affect male reproduction and induce signatures in gametes that may compromise the offspring healthSemantic proximity Read ↗

Sperm histone H3 lysine 4 tri-methylation serves as a metabolic sensor of paternal obesity and is associated with the inheritance of metabolic dysfunctionSemantic proximity Read ↗

Emerging evidence that the mammalian sperm epigenome serves as a template for embryo developmentSemantic proximity Read ↗

The preconception environment and sperm epigeneticsSemantic proximity Read ↗

Who's your daddy?: paternal inheritance of metabolic disease riskSemantic proximity Read ↗

Sperm Histone H3 Lysine 4 tri-methylation serves as a metabolic sensor of paternal obesity and is associated with the inheritance of metabolic dysfunctionSemantic proximity Read ↗

Paternal Obesity, Interventions, and Mechanistic Pathways to Impaired Health in OffspringSemantic proximity Read ↗

Sperm epigenome as a marker of environmental exposure and lifestyle, at the origin of diseases inheritanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.