Article

Sperm Histone H3 Lysine 4 tri-methylation serves as a metabolic sensor of paternal obesity and is associated with the inheritance of metabolic dysfunction

2021-09-11

Abstract excerpt

<h4>Objective</h4> Parental environmental exposures can strongly influence descendant risks for adult disease. How paternal obesity changes the sperm chromatin leading to the acquisition of metabolic disease in offspring remains controversial and ill-defined. The objective of this study was to assess: (1) whether obesity induced by a high-fat diet alters sperm histone methylation; (2) whether paternal obesity can...

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Literature Corpus work: 74445d0e-078e-5200-aaba-22e6c9d11c52
DOI: 10.1101/2021.09.09.459659

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