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Obesity-related DNA methylation at imprinted genes in human sperm: Results from the TIEGER study

6 May 2016

Abstract excerpt

BACKGROUND: Epigenetic reprogramming in mammalian gametes resets methylation marks that regulate monoallelic expression of imprinted genes. In males, this involves erasure of the maternal methylation marks and establishment of paternal-specific methylation to appropriately guide normal development. The degree to which exogenous factors influence the fidelity of methylation reprogramming is unknown. We previously...

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Share to Assisted Reproductive Technology and Twin Pregnancy
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PMID: 27158277
DOI: 10.1186/s13148-016-0217-2

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