Article

Predicting TCR antigen specificity at proteome-scale with synthetic immune cells and machine learning

2025-07-27

Abstract excerpt

TCR specificity to peptide-HLA antigens is central to immunology, impacting responses in infection, autoimmunity and cancer. Achieving precise recognition while avoiding off-target reactivity is critical for effective immunity and safe therapeutic interventions. Comprehensive, proteome-wide specificity profiling of TCRs is challenging with current methods, which notably lack integrated machine learning for large-s...

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Identifiers and source

Literature Corpus work: 37c739e2-c6dc-53b9-8941-486b12e01e7a
DOI: 10.1101/2025.07.23.666264

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