Article

Multi-strategies embedded framework for neoantigen vaccine maturation

2024-08-15

Abstract excerpt

Effective cancer immunotherapy hinges on the precise recognition of neoantigens, presented as binary complexes with major histocompatibility complex (MHC) molecules, by T cell receptors (TCR). The development of immunogenic peptide predictors and generators plays a central role in personalizing immunotherapies while reducing experimental costs. However, the current methods often fall short in leveraging structural...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 28d58c0c-a4a2-533c-957f-19c3c337c483
DOI: 10.1101/2024.08.14.607669

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multi-strategies embedded framework for neoantigen vaccine maturationDOI 10.1101/2024.08.14.607669Read

Automating neoantigen selection for personalized cancer vaccine designSemantic proximity Read

Best practices for bioinformatic characterization of neoantigens for clinical utility.Semantic proximity Read

Neo-intline: integrated pipeline enables neoantigen design through the in-silico presentation of T-cell epitopeSemantic proximity Read

Accelerating Neoantigen Discovery: A High-Throughput Approach to Immunogenic Target IdentificationSemantic proximity Read

Beyond MHC binding: immunogenicity prediction tools to refine neoantigen selection in cancer patientsSemantic proximity Read

NeoPrecis: enhancing immunotherapy response prediction through integration of qualified immunogenicity and clonality-aware neoantigen landscapes.Semantic proximity Read

Immune-based mutation classification enables neoantigen prioritization and immune feature discovery in cancer immunotherapy.Semantic proximity Read

Immune-based mutation classification enables neoantigen prioritization and immune feature discovery in cancer immunotherapySemantic proximity Read

VLP-mediated delivery of structure-selected neoantigens demonstrates immunogenicity and antitumoral activity in miceSemantic proximity Read

Transformer-Genetic Algorithm Co-Optimization for Neoantigen Prediction in Cancer ImmunotherapySemantic proximity Read

A comprehensive proteogenomic pipeline for neoantigen discovery to advance personalized cancer immunotherapySemantic proximity Read

Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction.Semantic proximity Read