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Article

A systematic safety pipeline for selection of T-cell receptors to enter clinical use

22 Aug 2023

Abstract excerpt

Cancer immunotherapy using T cell receptor-engineered T cells (TCR-Ts) represents a promising treatment option. However, technologies for pre-clinical safety assessment are incomplete or inaccessible to most laboratories. Here, TCR-T off-target reactivity was assessed in five steps: (1) Mapping target amino acids necessary for TCR-T recognition, followed by (2) a computational search for, and (3) reactivity...

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PMID: 37607971
DOI: 10.1038/s41541-023-00713-y

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