Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation.

Nature - 1 Dec 2016

Lin Juan, Kumari Snehlata, Kim Chun, Van Trieu-My, Wachsmuth Laurens, Polykratis Apostolos, Pasparakis Manolis

Abstract excerpt

Receptor-interacting protein kinase 1 (RIPK1) regulates cell death and inflammation through kinase-dependent and -independent functions. RIPK1 kinase activity induces caspase-8-dependent apoptosis and RIPK3 and mixed lineage kinase like (MLKL)-dependent necroptosis. In addition, RIPK1 inhibits apoptosis and necroptosis through kinase-independent functions, which are important for late embryonic development and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glycoproteins
Share to Keratinocytes
Share to Necrosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Domains

Share to Protein Kinases

Share to Receptor-Interacting Protein Serine-Threonine Kinases

Share to RNA-Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 27819681
DOI: 10.1038/nature20558
PMCID: PMC5755685

Genes

RIPK1
ZBP1
RIPK3
MLKL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation.PMID 27819681Read ↗

RIPK1 inhibits ZBP1-driven necroptosis during development.Semantic proximity Read ↗

The RIPK1 death domain restrains ZBP1- and TRIF-mediated cell death and inflammation.Semantic proximity Read ↗

Necroptosis in development and diseases.Semantic proximity Read ↗

Mapping where and when necroptotic cell death occurs in diseaseSemantic proximity Read ↗

The scaffold-dependent function of RIPK1 in dendritic cells promotes injury-induced colitisSemantic proximity Read ↗

Inhibitor of Apoptosis Proteins (IAPs) Limit RIPK1-Mediated Skin Inflammation.Semantic proximity Read ↗

ADAR1 mutation causes ZBP1-dependent immunopathology.Semantic proximity Read ↗

Z-DNA-binding protein 1-mediated programmed cell death: Mechanisms and therapeutic implicationsSemantic proximity Read ↗

RIPK1 ubiquitination regulates its kinase-independent function in development and inflammation.Semantic proximity Read ↗

ZBP1: A Powerful Innate Immune Sensor and Double-Edged Sword in Host ImmunitySemantic proximity Read ↗

Species-independent contribution of ZBP1/DAI/DLM-1-triggered necroptosis in host defense against HSV1Semantic proximity Read ↗

The regulation of the ZBP1‐NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis)Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.