Article
RIPK1 inhibits ZBP1-driven necroptosis during development.
Nature - 1 Dec 2016
Newton Kim, Wickliffe Katherine E, Maltzman Allie, Dugger Debra L, Strasser Andreas, Pham Victoria C, Lill Jennie R, Roose-Girma Merone, Warming Søren, Solon Margaret, Ngu Hai, Webster Joshua D, Dixit Vishva M
Abstract excerpt
Receptor-interacting protein kinase 1 (RIPK1) promotes cell survival-mice lacking RIPK1 die perinatally, exhibiting aberrant caspase-8-dependent apoptosis and mixed lineage kinase-like (MLKL)-dependent necroptosis. However, mice expressing catalytically inactive RIPK1 are viable, and an ill-defined pro-survival function for the RIPK1 scaffold has therefore been proposed. Here we show that the RIP homotypic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.