Article
RIPK1 ubiquitination regulates its kinase-independent function in development and inflammation.
Proceedings of the National Academy of Sciences of the United States of America - 14 Apr 2026
Li Ming, Liu Jianling, Xing Mingyan, Liu Han, Wang Lingxia, Wu Xiaoxia, Ou Yangjing, Zhao Xiaoming, Wang YangYang, Xie YangYang, Zhang Hanwen, Wu Zhuyang, Hao Jincheng, Li Hong, Li Yu, Zhang Haibing
Abstract excerpt
Receptor-interacting protein kinase 1 (RIPK1) is a key regulator of cell death and inflammation, with its activation modulated by diverse posttranslational modifications. While ubiquitination of RIPK1 at lysine 376 (K376) has been shown to inhibit apoptosis and necroptosis both in vitro and in vivo, its role in inflammation remains undefined. In this study, we introduced a kinase-dead D138N mutation into...
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