Article

Dysregulated functional and metabolic response in multiple sclerosis patient macrophages correlate with a more inflammatory state, reminiscent of trained immunity

2021-01-14

Abstract excerpt

In multiple sclerosis (MS), immune cells invade the central nervous system and destroy myelin. Macrophages contribute to demyelination and myelin repair, and their role in each process depends on their ability to acquire specific phenotypes in response to external signals. Here, we assess whether defects in MS patient macrophage responses may lead to increased inflammation or lack of neuro-regenerative effects. To...

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Literature Corpus work: da368a6d-82fd-55cd-a49a-f5283871aab6
DOI: 10.1101/2021.01.13.426327

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