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Article

Specific myeloid signatures in peripheral blood differentiate active and rare clinical phenotypes of multiple sclerosis.

Frontiers in immunology - 1 Jan 2023

Vakrakou Aigli G, Paschalidis Nikolaos, Pavlos Eleftherios, Giannouli Christina, Karathanasis Dimitris, Tsipota Xristina, Velonakis Georgios, Stadelmann-Nessler Christine, Evangelopoulos Maria-Eleftheria, Stefanis Leonidas, Kilidireas Constantinos

Abstract excerpt

Current understanding of Multiple Sclerosis (MS) pathophysiology implicates perturbations in adaptive cellular immune responses, predominantly T cells, in Relapsing-Remitting forms (RRMS). Nevertheless, from a clinical perspective MS is a heterogeneous disease reflecting the heterogeneity of involved biological systems. This complexity requires advanced analysis tools at the single-cell level to discover...

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PMID: 36761741
DOI: 10.3389/fimmu.2023.1071623
PMCID: PMC9905713

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