Article

Resource-efficient pooled sequencing expands translational impact in solid tumors

2021-06-07

Abstract excerpt

<h4>ABSTRACT</h4> Intratumoral genetic heterogeneity (ITH) poses a significant challenge to utilizing sequencing for decision making in the management of cancer. Although sequencing of multiple tumor regions can address the pitfalls of ITH, it does so at a significant increase in cost and resource utilization. We propose a pooled multiregional sequencing strategy, whereby DNA aliquots from multiple tumor regions...

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Literature Corpus work: da083432-0b58-5940-accd-cc0664213a4b
DOI: 10.1101/2021.06.06.447265

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