Article

Genetic demultiplexing of pooled single-cell RNA-sequencing samples in cancer facilitates effective experimental design

2020-11-07

Abstract excerpt

<h4>Background</h4> Pooling cells from multiple biological samples prior to library preparation within the same single-cell RNA sequencing experiment provides several advantages, including lower library preparation costs and reduced unwanted technological variation, such as batch effects. Computational demultiplexing tools based on natural genetic variation between individuals provide a simple approach to demulti...

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Literature Corpus work: 70ebaded-4e04-5966-b1bb-2aeb6a691673
DOI: 10.1101/2020.11.06.371963

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