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Article

Optimal detection of clinically relevant mutations in colorectal carcinoma: sample pooling overcomes intra-tumoral heterogeneity.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Feb 2018

Nelson Andrew C, Boone Jamie, Cartwright David, Thyagarajan Bharat, Kincaid Robyn, Lambert Aaron P, Karnuth Kylene, Henzler Christine, Yohe Sophia

Abstract excerpt

Intra-tumoral genomic heterogeneity is a well-established biologic property of human malignancies with emerging roles in cancer progression and therapy resistance. However, its impact on the clinical utility of genomic testing in patient management remains unclear. Furthermore, best practices to account for heterogeneity in the provision of highly accurate, clinically valid molecular testing have yet to be firmly...

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Identifiers

PMID: 29027537
DOI: 10.1038/modpathol.2017.120

Genes

KRAS
NRAS
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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