Article

Biased evolutionary inferences from bulk tumor samples

2016-11-25

Abstract excerpt

<h4>ABSTRACT</h4> It is generally agreed that tumors are composed of multiple cell clones defined by different somatic mutations. Characterizing the evolutionary mechanisms driving this intratumor genetic heterogeneity (ITH) is crucial to improve both cancer diagnosis and therapeutic strategies. For that purpose, recent ITH studies have focused on qualitative comparisons of mutational profiles derived from bulk s...

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Literature Corpus work: 046fec1c-a8db-5899-8b16-9e81c369fbda
DOI: 10.1101/089680

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