Article
Comparative Lesions Analysis Through a Targeted Sequencing Approach.
Journal of visualized experiments : JoVE - 5 Nov 2019
Vicentini Caterina, Mafficini Andrea, Simbolo Michele, Fassan Matteo, Delfino Pietro, Lawlor Rita Teresa, Rusev Borislav, Scarpa Aldo, Corbo Vincenzo
Abstract excerpt
Assessing intra-tumoral heterogeneity (ITH) is of paramount importance to anticipate failure of targeted therapies and design accordingly effective anti-tumor strategies. Although concerns are frequently raised due to differences in sample processing and depth of coverage, next-generation sequencing of solid tumors have unraveled a highly variable degree of ITH across tumor types. Capturing the genetic...
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