Article

Proof-of-concept pilot study on comprehensive spatiotemporal intra-patient heterogeneity for colorectal cancer with liver metastasis

2021-07-04

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Purpose</h4> The mechanisms underlying high drug resistance and relapse rates after multi-modal treatment in patients with colorectal cancer (CRC) and liver metastasis (LM) remain poorly understood. We evaluate the potential translational implications of intra-patient heterogeneity (IPH) comprising primary and matched metastatic intratumor heterogeneity (ITH) coupled with circulating tumor DN...

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Literature Corpus work: 9bd2b575-5d60-5054-b47d-583ab270ed71
DOI: 10.1101/2021.06.29.21259694

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