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Article

Comprehensive statistical inference of the clonal structure of cancer from multiple biopsies.

Scientific reports - 5 Dec 2017

Liu Jie, Halloran John T, Bilmes Jeffrey A, Daza Riza M, Lee Choli, Mahen Elisabeth M, Prunkard Donna, Song Chaozhong, Blau Sibel, Dorschner Michael O, Gadi Vijayakrishna K, Shendure Jay, Blau C Anthony, Noble William S

Abstract excerpt

A comprehensive characterization of tumor genetic heterogeneity is critical for understanding how cancers evolve and escape treatment. Although many algorithms have been developed for capturing tumor heterogeneity, they are designed for analyzing either a single type of genomic aberration or individual biopsies. Here we present THEMIS (Tumor Heterogeneity Extensible Modeling via an Integrative System), which...

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Identifiers

PMID: 29208983
DOI: 10.1038/s41598-017-16813-4
PMCID: PMC5717219

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THEMIS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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