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Genetic demultiplexing of pooled single-cell RNA-sequencing samples in cancer facilitates effective experimental design

1 Sept 2021

Abstract excerpt

BACKGROUND: Pooling cells from multiple biological samples prior to library preparation within the same single-cell RNA sequencing experiment provides several advantages, including lower library preparation costs and reduced unwanted technological variation, such as batch effects. Computational demultiplexing tools based on natural genetic variation between individuals provide a simple approach to demultiplex...

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PMID: 34553212
DOI: 10.1093/gigascience/giab062

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