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Oxidative Stress-Driven Cellular Senescence: Mechanistic Crosstalk and Therapeutic Horizons

12 Aug 2025

Abstract excerpt

Cellular senescence, a state of permanent cell cycle arrest, represents a double-edged sword in biology-providing tumor-suppressive functions while contributing to tissue degeneration, chronic inflammation, and age-related diseases when senescent cells persist. A key driver of senescence is oxidative stress, primarily mediated by excessive reactive oxygen species that damage mitochondrial DNA, modulate...

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PMID: 40867884
DOI: 10.3390/antiox14080987

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