Article

Targeting CyclinD1-CDK6 to Mitigate Senescence-Driven Inflammation and Age-Associated Functional Decline

2025-08-02

Abstract excerpt

Cellular senescence contributes to aging and age-related diseases by driving chronic inflammation through the Senescence Associated Secretory Phenotype (SASP) and interferon-stimulated genes (ISGs). Cyclin D1 (CCND1), a key cell cycle regulator, is paradoxically upregulated in these non-proliferating cells. We show that CCND1 and its kinase partner CDK6 drive SASP and ISG expression in senescent cells by promoting...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3dea8021-7b07-52cd-9bd9-4a68e5c0440b
DOI: 10.1101/2025.08.01.668243

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeting CyclinD1-CDK6 to Mitigate Senescence-Driven Inflammation and Age-Associated Functional DeclineDOI 10.1101/2025.08.01.668243Read

Pharmacological CDK4/6 inhibition unravels a p53-induced secretory phenotype in senescent cellsSemantic proximity Read

Pharmacological CDK4/6 inhibition reveals a p53‐dependent senescent state with restricted toxicitySemantic proximity Read

Linked regulation of genome integrity and senescence-associated inflammation by p53Semantic proximity Read

CDK4/6 inhibition induces a senescence-associated secretory phenotype via delayed NF-κB activation.Semantic proximity Read

Recent Advances in Anti‐Aging Therapeutic Strategies Targeting DNA Damage Response and Senescence‐Associated Secretory Phenotype‐Linked Signaling CascadeSemantic proximity Read

Age- and Tissue-Specific Expression of Senescence Biomarkers in MiceSemantic proximity Read

p21 regulates expression of ECM components and promotes pulmonary fibrosis via CDK4 and RbSemantic proximity Read

Tumor Suppressor and Aging Biomarker p16INK4a Induces Cellular Senescence without the Associated Inflammatory Secretory PhenotypeSemantic proximity Read

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.Semantic proximity Read

DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretionSemantic proximity Read

Cellular senescence and senescence-associated secretory phenotype via the cGAS-STING signaling pathway in cancer.Semantic proximity Read

Distinct secretomes in p16- and p21- positive senescent cells across tissuesSemantic proximity Read