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p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells

5 Mar 2025

Abstract excerpt

Genomic instability and inflammation are distinct hallmarks of aging, but the connection between them is poorly understood. Here we report a mechanism directly linking genomic instability and inflammation in senescent cells through a mitochondria-regulated molecular circuit involving p53 and cytoplasmic chromatin fragments (CCF) that are enriched for DNA damage signaling marker γH2A.X. We show that p53 suppresses...

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PMID: 40044657
DOI: 10.1038/s41467-025-57229-3

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