Article
Brain expression quantitative trait locus and network analyses reveal downstream effects and putative drivers for brain-related diseases.
Nature genetics - 1 Mar 2023
de Klein Niek, Tsai Ellen A, Vochteloo Martijn, Baird Denis, Huang Yunfeng, Chen Chia-Yen, van Dam Sipko, Oelen Roy, Deelen Patrick, Bakker Olivier B, El Garwany Omar, Ouyang Zhengyu, Marshall Eric E, Zavodszky Maria I, van Rheenen Wouter, Bakker Mark K, Veldink Jan, Gaunt Tom R, Runz Heiko, Franke Lude, Westra Harm-Jan
Abstract excerpt
Identification of therapeutic targets from genome-wide association studies (GWAS) requires insights into downstream functional consequences. We harmonized 8,613 RNA-sequencing samples from 14 brain datasets to create the MetaBrain resource and performed cis- and trans-expression quantitative trait locus (eQTL) meta-analyses in multiple brain region- and ancestry-specific datasets (n ≤ 2,759). Many of the 16,169...
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