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Article

The RNA binding domain of Pumilio antagonizes poly-adenosine binding protein and accelerates deadenylation.

RNA (New York, N.Y.) - 1 Aug 2014

Weidmann Chase A, Raynard Nathan A, Blewett Nathan H, Van Etten Jamie, Goldstrohm Aaron C

Abstract excerpt

PUF proteins are potent repressors that serve important roles in stem cell maintenance, neurological processes, and embryonic development. These functions are driven by PUF protein recognition of specific binding sites within the 3' untranslated regions of target mRNAs. In this study, we investigated mechanisms of repression by the founding PUF, Drosophila Pumilio, and its human orthologs. Here, we evaluated a...

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Source

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Identifiers

PMID: 24942623
DOI: 10.1261/rna.046029.114
PMCID: PMC4105754

Genes

PABPC1
PUM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The RNA binding domain of Pumilio antagonizes poly-adenosine binding protein and accelerates deadenylation.PMID 24942623Read ↗

Roles of Puf proteins in mRNA degradation and translation.Semantic proximity Read ↗

Targeted translational regulation using the PUF protein family scaffold.Semantic proximity Read ↗

Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptomeSemantic proximity Read ↗

Molecular Insights into mRNA Polyadenylation and DeadenylationSemantic proximity Read ↗

PUF protein-mediated deadenylation is catalyzed by Ccr4p.Semantic proximity Read ↗

Plant PUF RNA-binding proteins: A wealth of diversity for post-transcriptional gene regulation.Semantic proximity Read ↗

A role for the poly(A)-binding protein Pab1p in PUF protein-mediated repression.Semantic proximity Read ↗

The poly(A)-binding protein nuclear 1 suppresses alternative cleavage and polyadenylation sites.Semantic proximity Read ↗

Loss of nuclear poly(A)-binding protein 1 causes defects in myogenesis and mRNA biogenesisSemantic proximity Read ↗

A conserved abundant cytoplasmic long noncoding RNA modulates repression by Pumilio proteins in human cellsSemantic proximity Read ↗

To polyadenylate or to deadenylateSemantic proximity Read ↗

Function of Pumilio Genes in Human Embryonic Stem Cells and Their Effect in Stemness and CardiomyogenesisSemantic proximity Read ↗

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