Article

<i>Tbx5</i> maintains atrial identity by regulating an atrial enhancer network

2023-04-22

Abstract excerpt

Understanding how the atrial and ventricular chambers of the heart maintain their distinct identity is a prerequisite for treating chamber-specific diseases. Here, we selectively inactivated the transcription factor Tbx5 in the atrial working myocardium of the neonatal mouse heart to show that it is required to maintain atrial identity. Atrial Tbx5 inactivation downregulated highly chamber specific genes such as...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d9e4a2fb-534e-515d-8736-dddef6ae5f1d
DOI: 10.1101/2023.04.21.537535

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>Tbx5</i> maintains atrial identity by regulating an atrial enhancer networkDOI 10.1101/2023.04.21.537535Read

TBX5 and CHD4 Coordinately Activate Atrial Cardiomyocyte Genes to Maintain Cardiac Rhythm HomeostasisSemantic proximity Read

Reduced TBX5 dosage undermines developmental control of atrial cardiomyocyte identity in a model of human atrial diseaseSemantic proximity Read

Pitx2 modulates a Tbx5-dependent gene regulatory network to maintain atrial rhythm.Semantic proximity Read

Dynamics of Cardiomyocyte Transcriptome and Chromatin Landscape Demarcates Key Events of Heart DevelopmentSemantic proximity Read

Regulatory variation in a TBX5 enhancer leads to isolated congenital heart diseaseSemantic proximity Read

An atrial fibrillation-associated regulatory region modulates cardiac <i>Tbx5</i> levels and arrhythmia susceptibilitySemantic proximity Read

ATAC-Seq Reveals an Isl1 Enhancer That Regulates Sinoatrial Node Development and Function.Semantic proximity Read

Tbx20 Is Required in Mid-Gestation Cardiomyocytes and Plays a Central Role in Atrial Development.Semantic proximity Read

Modeling human <i>TBX5</i> haploinsufficiency predicts regulatory networks for congenital heart diseaseSemantic proximity Read

<i>Pitx2</i> prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specificationSemantic proximity Read

Modeling Human TBX5 Haploinsufficiency Predicts Regulatory Networks for Congenital Heart Disease.Semantic proximity Read

Tbx20 regulates a genetic program essential to adult mouse cardiomyocyte functionSemantic proximity Read