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Article

TBX5 and CHD4 Coordinately Activate Atrial Cardiomyocyte Genes to Maintain Cardiac Rhythm Homeostasis

13 Aug 2025

Abstract excerpt

BACKGROUND: Atrial fibrillation, the most common sustained arrhythmia, affects 59 million individuals worldwide. The transcription factor TBX5 (T-box 5) is essential for normal atrial rhythm. Its inactivation causes loss of atrial cardiomyocyte (aCM) enhancer accessibility, looping, transcriptional identity, and spontaneous atrial fibrillation. TBX5 interacts with CHD4 (chromodomain helicase DNA-binding protein...

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PMID: 40799140
DOI: 10.1161/circulationaha.125.073833

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TBX5 and CHD4 Coordinately Activate Atrial Cardiomyocyte Genes to Maintain Cardiac Rhythm HomeostasisPMID 40799140Read ↗

<i>Tbx5</i> maintains atrial identity by regulating an atrial enhancer networkSemantic proximity Read ↗

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Dynamics of Cardiomyocyte Transcriptome and Chromatin Landscape Demarcates Key Events of Heart DevelopmentSemantic proximity Read ↗

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