Article
ATAC-Seq Reveals an Isl1 Enhancer That Regulates Sinoatrial Node Development and Function.
Circulation research - 4 Dec 2020
Galang Giselle, Mandla Ravi, Ruan Hongmei, Jung Catherine, Sinha Tanvi, Stone Nicole R, Wu Roland S, Mannion Brandon J, Allu Prasanna K R, Chang Kevin, Rammohan Ashwin, Shi Marie B, Pennacchio Len A, Black Brian L, Vedantham Vasanth
Abstract excerpt
RATIONALE: Cardiac pacemaker cells (PCs) in the sinoatrial node (SAN) have a distinct gene expression program that allows them to fire automatically and initiate the heartbeat. Although critical SAN transcription factors, including Isl1 (Islet-1), Tbx3 (T-box transcription factor 3), and Shox2 (short-stature homeobox protein 2), have been identified, the cis-regulatory architecture that governs PC-specific gene...
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