Article

Modeling human <i>TBX5</i> haploinsufficiency predicts regulatory networks for congenital heart disease

2019-11-08

Abstract excerpt

Haploinsufficiency of transcriptional regulators causes human congenital heart disease (CHD). However, underlying CHD gene regulatory network (GRN) imbalances are unknown. Here, we define transcriptional consequences of reduced dosage of the CHD-linked transcription factor, TBX5, in individual cells during cardiomyocyte differentiation from human induced pluripotent stem cells (iPSCs). We discovered highly sensiti...

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Literature Corpus work: aae03f3c-9ed2-5c2a-bb7d-794e0d258aba
DOI: 10.1101/835603

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