Article

An atrial fibrillation-associated regulatory region modulates cardiac <i>Tbx5</i> levels and arrhythmia susceptibility

2022-05-14

Abstract excerpt

Heart development and rhythm control are highly Tbx5 dosage-sensitive. TBX5 haploinsufficiency causes congenital conduction disorders, whereas increased expression levels of TBX5 in human heart samples has been associated with atrial fibrillation. We deleted the conserved mouse orthologues of two independent AF-associated genomic regions in the Tbx5 locus, one intronic ( RE(int) -/- ) and one downstream of T...

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Literature Corpus work: d54cc0a3-2737-503f-82f7-0abd05ad31cf
DOI: 10.1101/2022.05.14.491627

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