Article

SCN9A gene therapy: Novel mechanism to inhibit cellular senescence in astrocytes <i>in vitro</i>

2023-07-24

Abstract excerpt

Cellular aging, also known as senescence, is a form of proliferation arrest that occurs in cells with age. In individuals, this process occurs due to telomere degradation and consequent dysfunction. In the nervous system, senescence of astrocytes, the most common neuronal support cells, has been associated with inflammation and forms of neurodegeneration associated with various disease pathologies. Thus, studying...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d9b9ec62-77cc-5fe9-ab79-932368652293
DOI: 10.1101/2023.07.24.549756

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SCN9A gene therapy: Novel mechanism to inhibit cellular senescence in astrocytes <i>in vitro</i>DOI 10.1101/2023.07.24.549756Read

<i>SCN9A</i>: Proposal of Voltage-Gated Ion Channels as a Novel Diagnostic Marker for Alzheimer’s DiseaseSemantic proximity Read

SerpinA3N Regulates the Secretory Phenotype of Mouse Senescent Astrocytes Contributing to Neurodegeneration.Semantic proximity Read

Astrocyte senescence: Evidence and significanceSemantic proximity Read

Changes in the Transcriptome of Human Astrocytes Accompanying Oxidative Stress-Induced SenescenceSemantic proximity Read

Senescent Phenotype of Astrocytes Leads to Microglia Activation and Neuronal DeathSemantic proximity Read

Senescent Astrocytes Derived from Human Pluripotent Stem Cells Reveal Age-Related Changes and Implications for NeurodegenerationSemantic proximity Read

MiR-302a reprogrammed fibroblast-derived induced anti-aging neural stem cells improve cognition and prolong lifespan in Alzheimer's disease modelSemantic proximity Read

Senescent Phenotype of Astrocytes Leads to Activation of BV2 Microglia and N2a Neuronal Cells Death.Semantic proximity Read

Doxorubicin Induces a Senescent Phenotype in Murine and Human AstrocytesSemantic proximity Read

Diverse but unique astrocytic phenotypes during embryonic stem cell differentiation, culturing and agingSemantic proximity Read

Chemically Induced Senescence in Human Stem Cell-Derived Neurons Promotes Phenotypic Presentation of NeurodegenerationSemantic proximity Read

Lessons from inducible pluripotent stem cell models on neuronal senescence in aging and neurodegenerationSemantic proximity Read