Article

Chemically Induced Senescence in Human Stem Cell-Derived Neurons Promotes Phenotypic Presentation of Neurodegeneration

2021-07-12

Abstract excerpt

<h4>Summary</h4> Modeling age-related neurodegenerative disorders with human stem cells is difficult due to the embryonic nature of stem cell derived neurons. We developed a chemical cocktail to induce senescence of iPSC-derived neurons to address this challenge. We first screened small molecules that induce embryonic fibroblasts to exhibit features characteristic of aged fibroblasts. We then optimized a cocktail...

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Literature Corpus work: 4ae15fa1-e740-561e-ba58-f0d7f5e6ab5e
DOI: 10.1101/2021.07.11.451956

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