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New Ref-1/APE1 targeted inhibitors demonstrating improved potency for clinical applications in multiple cancer types

2 Feb 2024

Abstract excerpt

AP endonuclease-1/Redox factor-1 (APE1/Ref-1 or Ref-1) is a multifunctional protein that is overexpressed in most aggressive cancers and impacts various cancer cell signaling pathways. Ref-1's redox activity plays a significant role in activating transcription factors (TFs) such as NFκB, HIF1α, STAT3 and AP-1, which are crucial contributors to the development of tumors and metastatic growth. Therefore,...

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PMID: 38311014
DOI: 10.1016/j.phrs.2024.107092

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