Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mass spectrometry analysis of the oxidation states of the pro-oncogenic protein anterior gradient-2 reveals covalent dimerization via an intermolecular disulphide bond.

Biochimica et biophysica acta - 1 May 2016

Clarke David J, Murray Euan, Faktor Jakub, Mohtar Aiman, Vojtesek Borek, MacKay C Logan, Smith Pat Langridge, Hupp Ted R

Abstract excerpt

Anterior Gradient-2 (AGR2) is a component of a pro-oncogenic signalling pathway that can promote p53 inhibition, metastatic cell migration, limb regeneration, and cancer drug-resistance. AGR2 is in the protein-disulphide isomerase superfamily containing a single cysteine (Cys-81) that forms covalent adducts with its client proteins. We have found that mutation of Cysteine-81 attenuates its biochemical activity in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATPases Associated with Diverse Cellular Activities
Share to Disulfides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Helicases

Share to Mass Spectrometry

Share to MCF-7 Cells

Share to Mucoproteins

Share to Oncogene Proteins

Share to Protein Multimerization

Source

Identifiers

PMID: 26876500
DOI: 10.1016/j.bbapap.2016.02.011

Genes

AGR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mass spectrometry analysis of the oxidation states of the pro-oncogenic protein anterior gradient-2 reveals covalent dimerization via an intermolecular disulphide bond.PMID 26876500Read ↗

Metastasis-promoting anterior gradient 2 protein has a dimeric thioredoxin fold structure and a role in cell adhesion.Semantic proximity Read ↗

Leveraging the Role of the Metastatic Associated Protein Anterior Gradient Homologue 2 in Unfolded Protein Degradation: A Novel Therapeutic Biomarker for CancerSemantic proximity Read ↗

Characterization of the AGR2 Interactome Uncovers New Players of Protein Disulfide Isomerase Network in Cancer CellsSemantic proximity Read ↗

Engineering a synthetic cell panel to identify signalling components reprogrammed by the cell growth regulator anterior gradient-2.Semantic proximity Read ↗

Identification, characterization and application of a new peptide against anterior gradient homolog 2 (AGR2)Semantic proximity Read ↗

Characterising the role of anterior gradient protein 2 in cell adhesion and metastasisSemantic proximity Read ↗

The protein disulfide isomerase AGR2 is essential for production of intestinal mucus.Semantic proximity Read ↗

Ninhydrin as a covalent warhead for chemical proteomic-enabled discovery and selective engagement of reactive argininesSemantic proximity Read ↗

The co-chaperone DNAJA2 buffers proteasomal degradation of cytosolic proteins with missense mutationsSemantic proximity Read ↗

Aberrant disulphide bonding contributes to the ER retention of alpha1-antitrypsin deficiency variants.Semantic proximity Read ↗

C-terminal amides mark proteins for degradation via SCF/FBXO31Semantic proximity Read ↗

Divergent Proteome Reactivity Influences Arm-Selective Activation of Pharmacological Endoplasmic Reticulum Proteostasis RegulatorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.