Article

Proteostasis as an Integrating Node: Metadichol Coordinately Induces the 22-Gene HSF1/SIRT1-Anchored Chaperone Network in Human PBMCs at Picogram Concentrations

2026-07-10

Abstract excerpt

<h4>Background: </h4> Protein homeostasis (proteostasis) is maintained by a network of heat shock proteins (HSPs) and co-chaperones spanning the cytosol, mitochondria, and endoplasmic reticulum, under the transcriptional control of heat shock factor 1 (HSF1) and its metabolic partner SIRT1. Metadichol, a nanoemulsion of long-chain alcohols and a pan-nuclear-receptor ligand, has been reported to modulate broad gene...

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Literature Corpus work: 4767e995-ac91-5c76-94d1-c3ee7c292cc8
DOI: 10.20944/preprints202607.0731.v1

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