Article

Transcriptomic profiling of epigenetic regulators and metabolic reprogramming in human cholangiocarcinoma

2025-12-13

Abstract excerpt

<h4>Background</h4> Epigenetic alterations play an increasingly recognized role in carcinogenesis and in the development of resistance to anticancer therapies. Epigenetic enzymes (writers and erasers) and effectors (readers) are largely influenced by the availability of metabolites grenerated through one-carbon metabolism (OCM), the tricarboxylic acid (TCA) cycle, and acetyl-CoA synthesis (ACS). In this study we...

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Literature Corpus work: 2fb40daa-b292-57d5-9978-5eff963847dc
DOI: 10.64898/2025.12.10.693445

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