Article

SNHG15 inhibits the tricarboxylic acid cycle and promotes HCC progression by facilitating the phosphorylation of PDK1 and PDHE1α

2026-04-23

Abstract excerpt

<title>Abstract</title> <p>Glucometabolic reprogramming is a defining feature of hepatocellular carcinoma (HCC). The pyruvate dehydrogenase complex (PDHc) serves as a critical intermediary between glycolysis and oxidative phosphorylation by facilitating the oxidation of pyruvate within the tricarboxylic acid cycle. However, its potential involvement in other facets of metabolic regulation has yet to be fully eluc...

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Literature Corpus work: 37fc7263-927d-5b06-af6b-30dfb7e8f221
DOI: 10.21203/rs.3.rs-9307919/v1

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