Article

Interrupting ELMSAN1 repression of nuclear acetyl-CoA production therapeutically reprograms cancer cells

2025-04-29

Abstract excerpt

<h4>SUMMARY</h4> Metabolites are essential substrates for epigenetic modifications. Although nuclear acetyl-CoA constitutes a small fraction of the whole cell pool, it regulates cell fate by locally providing histone acetylation substrate. Here, we combined phenotypic chemical screen and genome-wide CRISPR screen to demonstrate a nucleus-specific acetyl-CoA regulatory mechanism that can be modulated to achieve th...

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Literature Corpus work: 0f0b4db8-af6f-5233-b6d3-d2a77a24415c
DOI: 10.1101/2025.04.25.650293

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