Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Potential Role of Trained Immunity in Autoimmune and Autoinflammatory Disorders

19 Feb 2018

Abstract excerpt

During induction of trained immunity, monocytes and macrophages undergo a functional and transcriptional reprogramming toward increased activation. Important rewiring of cellular metabolism of the myeloid cells takes place during induction of trained immunity, including a shift toward glycolysis induced through the mTOR pathway, as well as glutaminolysis and cholesterol synthesis. Subsequently, this leads to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COVID-19 Impact on Reproduction
Share to Diabetes and associated disorders
Share to Immune responses and vaccinations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29515591
DOI: 10.3389/fimmu.2018.00298

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Potential Role of Trained Immunity in Autoimmune and Autoinflammatory DisordersPMID 29515591Read ↗

Immunometabolic circuits in trained immunitySemantic proximity Read ↗

The causes and consequences of trained immunity in myeloid cellsSemantic proximity Read ↗

Molecular and Cellular Mechanisms Modulating Trained Immunity by Various Cell Types in Response to Pathogen EncounterSemantic proximity Read ↗

Trained immunity as a novel therapeutic strategySemantic proximity Read ↗

Trained Innate Immunity Not Always AmicableSemantic proximity Read ↗

Trained immunity: adaptation within innate immune mechanismsSemantic proximity Read ↗

Potential impact of trained innate immunity on the pathophysiology of metabolic dysfunction-associated fatty liver diseaseSemantic proximity Read ↗

Trained immunity: General and emerging conceptsSemantic proximity Read ↗

The mechanisms and cross-protection of trained innate immunitySemantic proximity Read ↗

Infection-induced trained immunity: a twist in paradigm of innate host defense and generation of immunological memorySemantic proximity Read ↗

Hematopoietic stem cells are a reservoir for trained immunity in autoimmune diseaseSemantic proximity Read ↗

Trained immunity: A Yin‐Yang balanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.