Article

Single-cell RNA-seq reveals alterations in peripheral <i>CX3CR1</i> and nonclassical monocytes in familial tauopathy

2022-10-30

Abstract excerpt

<h4>Background</h4> Emerging evidence from mouse models is beginning to elucidate the brain’s immune response to tau pathology, but little is known about the nature of this response in humans. In addition, it remains unclear to what extent tau pathology and the local inflammatory response within the brain influence the broader immune system. <h4>Methods</h4> To address these questions, we performed single-cell R...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d9553c3d-4a3d-5646-a2cd-bb53d561722c
DOI: 10.1101/2022.10.28.514304

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell RNA-seq reveals alterations in peripheral <i>CX3CR1</i> and nonclassical monocytes in familial tauopathyDOI 10.1101/2022.10.28.514304Read

Single-cell RNA-seq reveals alterations in peripheral CX3CR1 and nonclassical monocytes in familial tauopathySemantic proximity Read

TIA1 Mediates Divergent Inflammatory Responses to Tauopathy in Microglia and MacrophagesSemantic proximity Read

Single-cell spatial transcriptomics reveals distinct patterns of dysregulation in non-neuronal and neuronal cells induced by the Trem2R47H Alzheimer's risk gene mutation.Semantic proximity Read

Deciphering the cell-intrinsic effect of DNMT3A clonal hematopoiesis in circulating monocytes: potential mechanistic insights into a protective role in Alzheimer’s diseaseSemantic proximity Read

Integrative genomics and single-cell CRISPRi screening dissect Alzheimer GWAS non-coding variants regulating TSPAN14.Semantic proximity Read

A Trem2*R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaquesSemantic proximity Read

Integration of transcriptional signatures from brain tissue and plasma extracellular vesicles of a preclinical tauopathy mouse modelSemantic proximity Read

Cell autonomous microglia defects in a stem cell model of frontotemporal dementiaSemantic proximity Read

Single cell and spatial transcriptomic analyses reveal microglia-plasma cell crosstalk in the brain during Trypanosoma brucei infectionSemantic proximity Read

Integrative single cell and spatial transcriptomic analysis reveal reciprocal microglia-plasma cell crosstalk in the mouse brain during chronic <i>Trypanosoma brucei</i> infectionSemantic proximity Read

Mutation-resolved single-cell transcriptomics reveals enhanced β-amyloid clearance in TET2-mutant human monocytes.Semantic proximity Read

Mechanobiological Specialization of Choroid Plexus Macrophages Defined by Titin ExpressionSemantic proximity Read