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Integrative single cell and spatial transcriptomic analysis reveal reciprocal microglia-plasma cell crosstalk in the mouse brain during chronic <i>Trypanosoma brucei</i> infection

2022-03-27

Abstract excerpt

Human African trypanosomiasis, or sleeping sickness, is caused by the protozoan parasite Trypanosoma brucei and induces profound reactivity of glial cells and neuroinflammation when the parasites colonise the central nervous system. However, the transcriptional and functional responses of the brain to chronic T. brucei infection remain poorly understood. By integrating single cell and spatial transcriptomics of...

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Literature Corpus work
96046f5a-51fe-5f8d-bb0b-2b028ca690bb
DOI
10.1101/2022.03.25.485502
Open publication

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