Article

TIA1 Mediates Divergent Inflammatory Responses to Tauopathy in Microglia and Macrophages

2024-11-07

Abstract excerpt

The RNA binding protein TIA1 is known to regulate stress responses. Here we show that TIA1 plays a much broader role in inflammatory cells, being required for the microglial sensome. We crossed TIA1 cKO mice (using a CX3CR1 driven cre element) to PS19 MAPT P301S tauopathy mice. The peripheral macrophages of TIA1 cKO mice exhibited a hyper-inflammatory phenotype with increased cytokine signaling, as expected. Surpr...

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Literature Corpus work: 0f552971-5f3e-5782-9bde-2917a367066c
DOI: 10.1101/2024.11.06.622325

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