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Article

CRISPR screens for functional interrogation of immunity.

Nature reviews. Immunology - 1 Jun 2023

Shi Hao, Doench John G, Chi Hongbo

Abstract excerpt

CRISPR-based technologies represent a major breakthrough in biomedical science as they offer a powerful platform for unbiased screening and functional genomics in various fields, including immunology. Pooled and arrayed CRISPR screens have uncovered previously unknown intracellular drivers in innate and adaptive immune cells for immune regulation as well as intercellular regulators mediating cell-cell...

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PMID: 36481809
DOI: 10.1038/s41577-022-00802-4

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