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Massive clonal expansion of medulloblastoma-specific T cells during adoptive cellular therapy

1 Nov 2019

Abstract excerpt

In both human and murine systems, we have developed an adoptive cellular therapy platform against medulloblastoma and glioblastoma that uses dendritic cells pulsed with a tumor RNA transcriptome to expand polyclonal tumor-reactive T cells against a plurality of antigens within heterogeneous brain tumors. We demonstrate that peripheral TCR Vβ repertoire analysis after adoptive cellular therapy reveals that...

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PMID: 31807694
DOI: 10.1126/sciadv.aav9879

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