Article

Replication stress causes delayed mitotic entry and Chromosome 12 fragility at the ANKS1B large neuronal gene in human induced pluripotent stem cells

2023-04-07

Abstract excerpt

Substantial background level of replication stress is a feature of embryonic and induced pluripotent stem cells (iPSCs), which can predispose to numerical and structural chromosomal instability, including recurrent aberrations of Chromosome 12. In differentiated cells, replication stress-sensitive genomic regions, including common fragile sites, are widely mapped through mitotic chromosome break induction by mild...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d92f9181-9186-5263-aaf4-70e4b63bf69f
DOI: 10.21203/rs.3.rs-2781849/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Replication stress causes delayed mitotic entry and Chromosome 12 fragility at the ANKS1B large neuronal gene in human induced pluripotent stem cellsDOI 10.21203/rs.3.rs-2781849/v1Read

Early replication fragile sites are associated with cancer-related CNVs and SNVs in human embryonic stem cells.Semantic proximity Read

Mechanisms of genomic instabilities underlying two common fragile-site-associated loci, PARK2 and DMD, in germ cell and cancer cell lines.Semantic proximity Read

Chromosomal instability at common fragile sites in Seckel syndrome.Semantic proximity Read

Origin of Chromosome 12 Trisomy Surge in Human Induced Pluripotent Stem Cells (iPSCs)Semantic proximity Read

Allele-specific late replication and fragility of the most active common fragile site, FRA3B.Semantic proximity Read

Locus-specific transcription silencing at the FHIT gene suppresses replication stress-induced copy number variant formation and associated replication delay.Semantic proximity Read

Genome-wide high-resolution mapping of mitotic DNA synthesis sites and common fragile sites by direct sequencing.Semantic proximity Read

BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function.Semantic proximity Read

Delayed DNA replication in haploid human embryonic stem cellsSemantic proximity Read

Molecular basis for expression of common and rare fragile sites.Semantic proximity Read

DNA Instability at Chromosomal Fragile Sites in CancerSemantic proximity Read

Replication stress and mechanisms of CNV formation.Semantic proximity Read