Article
Mechanisms of genomic instabilities underlying two common fragile-site-associated loci, PARK2 and DMD, in germ cell and cancer cell lines.
American journal of human genetics - 9 Jul 2010
Mitsui Jun, Takahashi Yuji, Goto Jun, Tomiyama Hiroyuki, Ishikawa Shunpei, Yoshino Hiroyo, Minami Narihiro, Smith David I, Lesage Suzanne, Aburatani Hiroyuki, Nishino Ichizo, Brice Alexis, Hattori Nobutaka, Tsuji Shoji
Abstract excerpt
Common fragile sites (CFSs) are specific chromosome regions that exhibit an increased frequency of breaks when cells are exposed to a DNA-replication inhibitor such as aphidicolin. PARK2 and DMD, the causative genes for autosomal-recessive juvenile Parkinsonism and Duchenne and Becker muscular dystrophy, respectively, are two very large genes that are located within aphidicolin-induced CFSs. Gross rearrangements...
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