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Article

Replication stress and mechanisms of CNV formation.

Current opinion in genetics & development - 1 Jun 2012

Arlt Martin F, Wilson Thomas E, Glover Thomas W

Abstract excerpt

Copy number variants (CNVs) are widely distributed throughout the human genome, where they contribute to genetic variation and phenotypic diversity. De novo CNVs are also a major cause of numerous genetic and developmental disorders. However, unlike many other types of mutations, little is known about the genetic and environmental risk factors for new and deleterious CNVs. DNA replication errors have been...

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Identifiers

PMID: 22365495
DOI: 10.1016/j.gde.2012.01.009
PMCID: PMC3371136

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