Article
Allele-specific late replication and fragility of the most active common fragile site, FRA3B.
Human molecular genetics - 1 Mar 1999
Wang L, Darling J, Zhang J S, Huang H, Liu W, Smith D I
Abstract excerpt
FRA3B at 3p14.2 is the most active of the common fragile sites in the human genome and is expressed when cells are exposed to the DNA replication inhibitor, aphidicolin. Several lines of evidence suggest that fragile sites are regions of late replication. To elucidate the relationship between the timing of replication across the FRA3B region and its corresponding fragility, we labeled cells with...
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