Allele-specific late replication and fragility of the most active common fragile site, FRA3B.

doi:10.1093/hmg/8.3.431

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Article

Allele-specific late replication and fragility of the most active common fragile site, FRA3B.

Human molecular genetics - 1 Mar 1999

Wang L, Darling J, Zhang J S, Huang H, Liu W, Smith D I

Abstract excerpt

FRA3B at 3p14.2 is the most active of the common fragile sites in the human genome and is expressed when cells are exposed to the DNA replication inhibitor, aphidicolin. Several lines of evidence suggest that fragile sites are regions of late replication. To elucidate the relationship between the...

Topics

Acid Anhydride Hydrolases
Alleles
Base Sequence
Cell Line
Chromosome Fragile Sites
Chromosome Fragility
Chromosomes, Human, Pair 3
DNA Primers
DNA Replication
Humans
In Situ Hybridization, Fluorescence
Neoplasm Proteins
Polymerase Chain Reaction
Proteins
Time Factors

Source

Open in PubMed

Identifiers

PMID: 9949202
DOI: 10.1093/hmg/8.3.431

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9949202-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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