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Article

BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function.

Molecular and cellular biology - 1 Aug 2004

Arlt Martin F, Xu Bo, Durkin Sandra G, Casper Anne M, Kastan Michael B, Glover Thomas W

Abstract excerpt

Common fragile sites are loci that form chromosome gaps or breaks when DNA synthesis is partially inhibited. Fragile sites are prone to deletions, translocations, and other rearrangements that can cause the inactivation of associated tumor suppressor genes in cancer cells. It was previously shown that ATR is critical to fragile-site stability and that ATR-deficient cells have greatly elevated fragile-site...

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Source

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Identifiers

PMID: 15254237
DOI: 10.1128/MCB.24.15.6701-6709.2004
PMCID: PMC444841

Genes

BRCA1
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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